Aerobic copper-catalyzed oxidative [6C+1C] annulation: an efficient route to seven-membered carbocycles.
نویسندگان
چکیده
It has been revealed for the first time that co-promoted by CuCl and NaH in the presence of molecular oxygen (air), the reaction of dicinnamoyl ketene dithioacetals as the acyclic C6 synthons with ethyl cyanoacetate gives functionalized seven-membered carbocycles. A mechanism is proposed involving a tandem Michael addition-intramolecular radical cyclization-benzyl C(sp(3))-H bond oxidation.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 63 شماره
صفحات -
تاریخ انتشار 2014